|
KMID : 0370019940080000133
|
|
Chung-Ang Journal of Pharmacal Sciences
1994 Volume.8 No. 0 p.133 ~ p.143
|
|
|
Syntheses and Antimicrobial Activities of Thiocarbamyl Ciprofloxacin Derivatives
|
|
|
|
|
Abstract
|
|
|
Ten new thiocarbamyl ciprofloxacin derivatives and six their pivaloyloxymethyl esters were synthesized and evaluated for their antibacterial activity in vitro.
Compound［11］,N-methylthiocarbamyl ciprofloxacin exhibited the growth inhibitory activity at a concentration of 0.5㎍/ml against S. aureus SG 511, 0.12㎍/ml against Ps. aeruginosa 1771M and 0.06㎍/ml against Ps. aeruginosa 1592E.
In general, aliphatic substituted thiocarbamyl ciprofloxacin showed more potent antibacterial activity than aromatic substituted thiocarbamyl ciprofloxacins.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|